Tg(CSNK1D*,-EGFP)827Yfu
Transgene Detail

Summary

• Symbol: Tg(CSNK1D*,-EGFP)827Yfu
• Name: transgene insertion 827, Ying-Hui Fu
• MGI ID: MGI:3837566
• Synonyms: hCKIdelta-T44A H, Tg(CSNK1D*)827Yfu
• Transgene: Tg(CSNK1D*,-EGFP)827Yfu Location: unknown
• Alliance: Tg(CSNK1D*,-EGFP)827Yfu page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CSNK1D*,-EGFP)827Yfu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CSNK1D (1453)

  Csnk1d

  (MGI:1355272)

• Mutation details: The human BAC clone RP11-1376P16 containing the CSNK1D gene was targeted to generate a threonine-to-alanine alteration at amino acid 44 in the protein (T44A). An IRES-GFP cassette was also inserted after the stop codon of the CSNK1D gene. Six lines were generated with two of the lines, 827 and 859, being high expressers due to insertion of 2 to 3 copies of the transgene. Transgene expression was confirmed by RT-PCR of brain lysates. This is a representative record for the two high expressing lines. (J:97658)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:97658 Xu Y, et al., Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31;434(7033):640-4
• All: 2 reference(s)