Hyal2^tm1.1Bfla
Targeted Allele Detail

Summary

• Symbol: Hyal2^tm1.1Bfla
• Name: hyaluronoglucosaminidase 2; targeted mutation 1.1, Bruno Flamion
• MGI ID: MGI:3836764
• Gene: Hyal2 Location: Chr9:107445144-107449978 bp, + strand Genetic Position: Chr9, 58.12 cM
• Alliance: Hyal2^tm1.1Bfla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146040
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exons 2 through 4 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR on liver and kindey extracts. (J:146040)

Expression

In Mice Carrying this Mutation:	35 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hyal2 Mutation: 22 strains or lines available

References

• Original: J:146040 Jadin L, et al., Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008 Dec;22(12):4316-26
• All: 8 reference(s)