Ercc3^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Ercc3^tm1Jhjh
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 3; targeted mutation 1, Jan H J Hoeijmakers
• MGI ID: MGI:3836421
• Synonyms: Xpb^fs
• Gene: Ercc3 Location: Chr18:32373357-32403206 bp, + strand Genetic Position: Chr18, 17.97 cM, cytoband B3
• Alliance: Ercc3^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Four bases (GATC) were inserted after the first codon in exon 15 and result in a frameshift that replaces the 41 C-terminal amino acids with 85 nonsense residues. Expression levels are 10-fold lower than in wild-type mice as confirmed by RT-PCR. (J:145759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc3 Mutation: 31 strains or lines available

References

• Original: J:145759 Andressoo JO, et al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol. 2009 Mar;29(5):1276-90
• All: 1 reference(s)