Eamcd1^A/WySn
QTL Variant Detail

Summary

• QTL variant: Eamcd1^A/WySn
• Name: experimental autoimmune myocarditis 1; A/WySn
• MGI ID: MGI:3836283
• QTL: Eamcd1 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: A/WySn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to experimentally induced autoimmune myocarditis and decreased antigen-stimulated T-cell apoptosis compared to C57BL/10J. (J:145043)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:145043

A previously mapped genetic locus on mouse Chromosome 1 exhibiting suggestive linkage to autoimmune myocarditis susceptibility was confirmed in this study using congenic line analysis. A 50 cM region (D1Mit65 to D1Mit334) containing Eamcd1 (experimental autoimmune myocarditis 1) derived from myocarditis susceptible strain A.SW-H2^s/J was isolated on a resistant B10.S-H2^s/J genetic background. This congenic line displays increased incidence of autoimmune myocarditis and is designated B10.A-(D1Mit65-D1Mit334). Experimental autoimmune myocarditis is characterized by the production of cardiac-specfic autoantibodies and diffuse mononuclear infiltratation after immunization with mouse cardiac myosin. Congenic animals also displayed decreased activation of caspase 3, 8 and 9 in CD4+ T cells after myosin antigen challenge. However, the severity of induced autoimmune myocarditis in B10.A-(D1Mit65-D1Mit334) congenic animals is lessened compared to that of susceptible donor strain A.SW.

Icos (32 cM) and Il1r2 (19.5 cM) are two potential candidate genes located in the Eamcd1 QTL interval from 8.4 cM to 49.7 cM. Following myosin antigen challenge, Icos and Il1r2 mRNA expression is higher in the lymph nodes of B10.S-H2^s/J mice compared to A.SW-H2^s/J mice.

References

• Original: J:145043 Ligons DL, et al., A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death. Clin Immunol. 2009 Jan;130(1):74-82
• All: 1 reference(s)