Tg(Myh6-Pln)1Egk
Transgene Detail

Summary

• Symbol: Tg(Myh6-Pln)1Egk
• Name: transgene insertion 1, Evangelia G Kranias
• MGI ID: MGI:3834216
• Synonyms: PLB-WT, Tg(Pln)1Egk
• Transgene: Tg(Myh6-Pln)1Egk Location: unknown
• Alliance: Tg(Myh6-Pln)1Egk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Pln)1Egk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pln (MGI:97622)

• Mutation details: The transgene contains a wild-type mouse cardiac phospholamban cDNA, followed by an SV40 polyadenylation signal, under control of the cardiac-specific alpha myosin heavy chain (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. Northern blot analysis revealed expression of the 1.0 kb transcript from the transgene and Western blot analysis demonstrated phospholamban protein expression in the hearts of transgenic mice homozygous for a null phospholamban allele. (J:119619)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:119619 Luo W, et al., Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem. 1998 Feb 20;273(8):4734-9
• All: 3 reference(s)