Tg(Nes-Emx2)1Ddmo
Transgene Detail

Summary

• Symbol: Tg(Nes-Emx2)1Ddmo
• Name: transgene insertion 1, Dennis DM O'Leary
• MGI ID: MGI:3832278
• Synonyms: ne-Emx2
• Transgene: Tg(Nes-Emx2)1Ddmo Location: unknown
• Alliance: Tg(Nes-Emx2)1Ddmo page

Transgene origin

• Strain of Origin: (C57BL/6 x BALB/c)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Nes-Emx2)1Ddmo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Emx2 (499380)

  Emx2	(MGI:95388)

• Mutation details: A 5.8 kb fragment of rat nestin promoter sequence drives expression of a 0.8 kb rat Emx2 cDNA, which is 100% identical in sequence to mouse Emx2. These sequences are followed by a SV40 polyA signal, trailed by a 5.4 kb nestin genomic sequence, that provides enhancer activity. Expression is detectable by in situ hybridization at E14.5, a peak of cortical neurogenesis, of combined expression of endogenous and transgene-expressed Emx2 in transgenic mice. In transgenic mice, a high caudomedial to low rostrolateral gradient of Emx2 transcripts is evident in the cortical VZ, and expression is higher than that in controls. Enhanced Emx2 expression is also evident in the ganglionic eminence of transgenic mice, and moderate expression is detected in other nestin-positive proliferative zones, such as in dTh, where expression is not detected in controls. (J:96705)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96705 Hamasaki T, et al., EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors. Neuron. 2004 Aug 5;43(3):359-72
• All: 3 reference(s)