Spry1^tm2Jdli
Targeted Allele Detail

Summary

• Symbol: Spry1^tm2Jdli
• Name: sprouty RTK signaling antagonist 1; targeted mutation 2, Jonathan D Licht
• MGI ID: MGI:3832050
• Synonyms: Sprouty1^lacZ, Spry^lacZ
• Gene: Spry1 Location: Chr3:37694096-37698747 bp, + strand Genetic Position: Chr3, 18.46 cM
• Alliance: Spry1^tm2Jdli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES0lacZ and a floxed Neomycin selection cassette replaced the 3' half of exon 3 including part of the open reading frame. Mice with this modified allele were crossed with beta-actin cre deleter mice to excise neomycin. (J:144775)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry1 Mutation: 14 strains or lines available

References

• Original: J:144775 Thum T, et al., MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008 Dec 18;456(7224):980-4
• All: 11 reference(s)