Tg(Gcg-TGFB1)1Itak
Transgene Detail

Summary

• Symbol: Tg(Gcg-TGFB1)1Itak
• Name: transgene insertion 1, Mitsuo Itakura
• MGI ID: MGI:3831665
• Transgene: Tg(Gcg-TGFB1)1Itak Location: unknown
• Alliance: Tg(Gcg-TGFB1)1Itak page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gcg-TGFB1)1Itak expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	TGFB1 (397078)

• Mutation details: The cDNA for porcine TGFB1 was modified so that the codons for amino acid residues 223 and 225 that normally encode cysteine now encode serine. This cDNA was place under the control of the rat glucagon promoter. (J:109797)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:109797 Moritani M, et al., Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1. J Clin Invest. 1998 Aug 1;102(3):499-506
• All: 2 reference(s)