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Gene trapped Allele Detail
Symbol: Gtf2ird1Gt(XE465)Byg
Name: general transcription factor II I repeat domain-containing 1; gene trap XE465, BayGenomics
MGI ID: MGI:3831526
Synonyms: Gtf2ird1-
Gene: Gtf2ird1  Location: Chr5:134386510-134485570 bp, - strand  Genetic Position: Chr5, 74.55 cM
Alliance: Gtf2ird1Gt(XE465)Byg page
Craniofacial, vascular, allantois and other defects in Gtf2iGt(XE029)Byg/Gtf2iGt(XE029)Byg and Gtf2ird1Gt(XE465)Byg/Gtf2ird1Gt(XE465)Byg embryos at E9.5 - E12.5

Show the 3 phenotype image(s) involving this allele.

Mutant Cell Line:  XE465
Germline Transmission:  Earliest citation of germline transmission: J:143508
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
Mutation detailsA gene trap vector pGT1Lxf containing beta-geo was inserted into intron 22 upstream of the functional nuclear localization signal. (J:143508)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gtf2ird1 Mutation:  345 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:143508 Enkhmandakh B, et al., Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):181-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory