Tg(Prnp-ATN1)84Dbo
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATN1)84Dbo
• Name: transgene insertion 84, David R Borchelt
• MGI ID: MGI:3831325
• Synonyms: AT-FL-26Q-84
• Transgene: Tg(Prnp-ATN1)84Dbo Location: unknown
• Alliance: Tg(Prnp-ATN1)84Dbo page

Transgene origin

• Strain of Origin: (C3H x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATN1)84Dbo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATN1 (1822)

  Atn1	(MGI:104725)

• Mutation details: The transgene comprises a cDNA encoding full length human atrophin 1 containing a 26 residue polyglutamine tract, encoded by 26 CAG repeats, inserted into an expression cassette containing the promoter, 5' intronic and 5' and 3' untranslated region sequences of the mouse prion protein gene. This transgenic line carries more than ten copies of the construct. Northern blot analysis shows similar levels of expression of human atrophin 1 and native prion protein mRNA in the brain, where presence of the human protein is confirmed by immunoblot analysis. (J:70362)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70362 Schilling G, et al., Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 1999 Sep;24(1):275-86
• All: 3 reference(s)