Bub1^tm1.1Tvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm1.1Tvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 1.1, Terry Van Dyke
• MGI ID: MGI:3830859
• Synonyms: Bub1^delta2-3
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm1.1Tvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143035
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the exons 2 and 3 as well as the neo cassette. Removal of these exons results in a frameshift in exon 4 and a premature termination codon in exon 6. The absence of full-length protein product and the presence of a truncated one was confirmed by western blot analysis. (J:143035)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:143035 Schliekelman M, et al., Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res. 2009 Jan 1;69(1):45-54
• All: 1 reference(s)