Adarb1^tm1.1Eme
Targeted Allele Detail

Summary

• Symbol: Adarb1^tm1.1Eme
• Name: adenosine deaminase, RNA-specific, B1; targeted mutation 1.1, Ronald Emeson
• MGI ID: MGI:3830729
• Synonyms: deltaECS
• Gene: Adarb1 Location: Chr10:77126560-77254104 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Adarb1^tm1.1Eme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The editing site complementary sequence (ECS) region was deleted via Cre mediated recombination of Adarb1^tm1Eme. Quantification of pre-rRNA transcripts from homozygous mice indicated the autoediting was essentially absent. Western blot analysis indicated that expression of the full length protein is increased in the lung, brain , and heart of homozygous mice. (J:144148)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adarb1 Mutation: 35 strains or lines available

References

• Original: J:144148 Feng Y, et al., Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol. 2006 Jan;26(2):480-8
• All: 1 reference(s)