Tg(Gzmb-cre/ERT2)1Dtf
Transgene Detail

Summary

• Symbol: Tg(Gzmb-cre/ERT2)1Dtf
• Name: transgene insertion 1, Douglas T Fearon
• MGI ID: MGI:3830652
• Synonyms: gzmBCreER^T2
• Transgene: Tg(Gzmb-cre/ERT2)1Dtf Location: unknown
• Alliance: Tg(Gzmb-cre/ERT2)1Dtf page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Gzmb-cre/ERT2)1Dtf expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gzmb (MGI:109267)

• Mutation details: A BAC transgenic mouse was created by using a 155 kb fragment of murine chromosome 14 that had been modified by replacing the start codon of the granzyme B gene with the tamoxifen-dependent recombinase Cre/ERT2 gene. Successful integration of the construct was confirmed through genomic PCR. After crossing to a cre reporter strain and administrating tamoxifen, cre expression was detected in activated CD8 T cells and in NK cells. (J:144174)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gzmb (mouse) Summary of all recombinase alleles driven by Gzmb. Alliance mouse Gzmb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144174 Bannard O, et al., Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science. 2009 Jan 23;323(5913):505-9
• All: 5 reference(s)