Erap1^tm1Gnie
Targeted Allele Detail

Summary

• Symbol: Erap1^tm1Gnie
• Name: endoplasmic reticulum aminopeptidase 1; targeted mutation 1, Gabriele Niedermann
• MGI ID: MGI:3830213
• Gene: Erap1 Location: Chr13:74787692-74841321 bp, + strand Genetic Position: Chr13, 40.48 cM, cytoband C1
• Alliance: Erap1^tm1Gnie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143988
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 4 floxed. (J:143988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erap1 Mutation: 57 strains or lines available

References

• Original: J:143988 Firat E, et al., The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation. J Immunol. 2007 Feb 15;178(4):2241-8
• All: 2 reference(s)