Drd1^tm1Tono
Targeted Allele Detail

Summary

• Symbol: Drd1^tm1Tono
• Name: dopamine receptor D1; targeted mutation 1, Taketoshi Ono
• MGI ID: MGI:3829942
• Synonyms: D1R^-, Drd1a^tm1Mok, Drd1^tm1Mok
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^tm1Tono page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143054
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with an xanthine-guanine phosphoribosyl transferase gene and neo cassette. The absence of protein expression was confirmed by western blot analysis on adult brain extracts. (J:143054)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 68 strains or lines available

References

• Original: J:143054 Tran AH, et al., Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty. J Neurosci. 2008 Dec 10;28(50):13390-400
• All: 6 reference(s)