Rictor^tm1Rueg
Targeted Allele Detail

Summary

• Symbol: Rictor^tm1Rueg
• Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1, Markus Ruegg
• MGI ID: MGI:3829768
• Synonyms: mTORC2^fl, rictor^fl
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^tm1Rueg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143748
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 4 and 5 floxed. (J:143748)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 140 strains or lines available

References

• Original: J:143748 Bentzinger CF, et al., Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 2008 Nov;8(5):411-24
• All: 29 reference(s)