Prss21^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Prss21^tm1Tba
• Name: serine protease 21; targeted mutation 1, Tadashi Baba
• MGI ID: MGI:3829187
• Synonyms: Prss21^-
• Gene: Prss21 Location: Chr17:24087046-24092087 bp, + strand Genetic Position: Chr17, 12.11 cM, cytoband A3.3-B
• Alliance: Prss21^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142458
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 204-nucleotide protein-coding region of first three exons are replaced with a neo cassette. Immunoblot analysis of testicular germ cell and cauda epididymal sperm confirmed complete lack of protein product. (J:142458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prss21 Mutation: 13 strains or lines available

References

• Original: J:142458 Yamashita M, et al., Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells. 2008 Oct;13(10):1001-13
• All: 3 reference(s)