Tgq19^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tgq19^DBA/2J
• Name: triglyceride QTL 19; DBA/2J
• MGI ID: MGI:3828324
• QTL: Tgq19 Location: Chr9:4060750-4060750 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma triglyceride concentrations after 3 and 8 weeks of high fat diet compared to DBA/1J. (J:142770)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1J and (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

Tgq19 (triglyceride QTL 19) on mouse Chromosome 9 is linked to plasma triglycerides after 3 and 8 weeks of high fat diet. Peak association to 3-week triglycerides occurs at 18 cM (LOD=4.1) and peak association to 8-week triglycerides occurs at 6 cM (LOD=4.7). The peak marker is rs3023961 (4 Mb) [Table 2 and 3]. DBA/2J-derived alleles at Tgq19 confer increased plasma triglycerides. The QTL confidence interval spans 0 cM to 20 cM.

Significant linkage to HDL concentrationafter 8 week high fat diet mapped to 1 cM with LOD=4.1. This locus is named Hdlq62 (HDL QTL 62).

References

• Original: J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
• All: 1 reference(s)