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Tgq17DBA/2J
QTL Variant Detail
Summary
QTL variant: Tgq17DBA/2J
Name: triglyceride QTL 17; DBA/2J
MGI ID: MGI:3828320
QTL: Tgq17  Location: Chr4:129523489-129523489 bp  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  DBA/2J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers increased plasma triglyceride concentration in males after 8 weeks of high fat diet compared to DBA/1J. (J:142770)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes
Tgq17 is male-specific.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:142770

Linkage analysis was performed using a backcross derived from closely related inbred strains DBA/1J and DBA/2J. The genetic composition of these 2 inbred strains differs by just 5.6% at the SNP level. A total of 294 mice from (DBA/1J x DBA/2J)F1 x DBA/1Jand (DBA/1J x DBA/2J)F1 x DBA/2J populations were screened for 6,949 polymorphic SNP markers. Backcross mice were placed on a high-fat diet at 8 weeks of age and phenotyped for plasma triglyceride and HDL concentrations at 8, 11 and 16 weeks of age. Parental strain DBA/2J displays significantly increased plasma triglyceride concentrations on a CHOW diet compared to parental strain DBA/1J. Male DBA/2J animals display significantly increased plasma triglyceride and HDL concentrations after an 8 week high fat diet compared to DBA/1J males.

On mouse Chromosome 4, suggestive linkage to plasma triglycerides on an 8 week CHOW diet mapped to 45 cM and is named Tgq16 (triglyceride QTL 16) with LOD=3.5. [Table 2.]

Significant linkage to triglycerides in males after an 8 week high fat diet mapped to 68 cM at peak marker rs3708285 (LOD=4.4) and is named Tgq17. DBA/2J-derived alleles at Tgq17 confer increased triglycerides in males. The QTL confidence interval for Tgq17 spans 40 - 75 cM. [Table 3].

Significant linkage to HDL cholesterol concentration after 8 weeks on a high fat diet (LOD=2.9) mapped to 64 cM on Chromosome 4 and is named Hdlq64 (HDL QTL 64).

References
Original:  J:142770 Stylianou IM, et al., Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 Nov;49(11):2402-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory