Prnp^tm1Aag
Targeted Allele Detail

Summary

• Symbol: Prnp^tm1Aag
• Name: prion protein; targeted mutation 1, Adriano Aguzzi
• MGI ID: MGI:3826443
• Synonyms: Prnp^GFP
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp^tm1Aag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142638
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, RMCE-ready, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cassette exchange was used to replace the entire coding region located within exon 3 with an EGFP gene. (J:142638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 143 strains or lines available

References

• Original: J:142638 Heikenwalder M, et al., Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec;29(6):998-1008
• All: 5 reference(s)