Ptk2^tm1.1Jtpa
Targeted Allele Detail

Summary

• Symbol: Ptk2^tm1.1Jtpa
• Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.1, J Thomas Parsons
• MGI ID: MGI:3821611
• Gene: Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
• Alliance: Ptk2^tm1.1Jtpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142495
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the non-coding LE exon and a floxed neo cassette was inserted downstream of it. Transient cre expression was used to remove the neo cassette and LE exon. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:142495)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2 Mutation: 90 strains or lines available

References

• Original: J:142495 Hayasaka H, et al., Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene. J Cell Biochem. 2007 Nov 1;102(4):947-54
• All: 4 reference(s)