Tg(HBX-HCVE1,HCVE2)1Kko
Transgene Detail

Summary

• Symbol: Tg(HBX-HCVE1,HCVE2)1Kko
• Name: transgene insertion 1, Kazuhiko Koike
• MGI ID: MGI:3820858
• Synonyms: Tg(HCVE)
• Transgene: Tg(HBX-HCVE1,HCVE2)1Kko Location: unknown
• Alliance: Tg(HBX-HCVE1,HCVE2)1Kko page

Transgene origin

• Strain of Origin: Crlj:CD-1(ICR)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains the coding sequences for the hepatitis C virus (HCV) envelope proteins, E1 and E2, downstream of the enhancer and promoter from the HBx antigen gene of hepatitis B virus (HBV) and followed by the HBX polyadenylation signal. Both HCV envelope proteins are expressed in organs of transgenic mice, most strongly in the liver, where they occur in association with one another and primarily in the cytoplasm of hepatocytes surrounding the hepatic central veins. (J:129014)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This record represents two transgenic lines derived from independent founder mice, designated E101 and E139; a third line, E118, was not characterized.

References

• Original: J:129014 Koike K, et al., Expression of hepatitis C virus envelope proteins in transgenic mice. J Gen Virol. 1995 Dec;76(Pt 12):3031-8
• All: 1 reference(s)