Sell^tm3Tft
Targeted Allele Detail

Summary

• Symbol: Sell^tm3Tft
• Name: selectin, lymphocyte; targeted mutation 3, Thomas F Tedder
• MGI ID: MGI:3820623
• Synonyms: Ldelta
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^tm3Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142184
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The membrane-proximal region encoding a TNRSFSKIK motif was removed by homologous recombination leaving the rest of the coding sequence in-frame. A floxed neomycin cassette was included for targeting purposes downstream from the transmembrane encoding region. Mice homozygous for this mutation do not express protein on the cell surface of lymphocytes. (J:142184)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 41 strains or lines available

References

• Original: J:142184 Venturi GM, et al., Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity. 2003 Nov;19(5):713-24
• All: 1 reference(s)