Sumo1^Gt(XA024)Byg
Gene trapped Allele Detail

Summary

• Symbol: Sumo1^Gt(XA024)Byg
• Name: small ubiquitin-like modifier 1; gene trap XA024, BayGenomics
• MGI ID: MGI:3819343
• Gene: Sumo1 Location: Chr1:59678593-59709993 bp, - strand Genetic Position: Chr1, 30.32 cM, cytoband C2-C3
• Alliance: Sumo1^Gt(XA024)Byg page

Mutation origin

• Mutant Cell Line: XA024
• Germline Transmission: Earliest citation of germline transmission: J:141678
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: The gene trap is inserted in the first intron at the 3' end. The last 754 nucleotides of the intron and the first nucleotide of exon 2 are deleted. The splice acceptor for exon 2 is lost. In addition to a transcript containing gene trap vector sequences, a transcript resulting from splicing exon 1 to exon 3 is expressed. (J:141678)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XA024	CC144540 ; (MGI Seq Detail)	5' RACE	Chr1:59709843-59709960 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  137 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sumo1 Mutation: 66 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141678 Evdokimov E, et al., Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J Cell Sci. 2008 Dec 15;121(Pt 24):4106-13
• All: 5 reference(s)