Sf1^{Gt(pU17)1Teya}
Gene trapped Allele Detail

Summary

• Symbol: Sf1^{Gt(pU17)1Teya}
• Name: splicing factor 1; gene trap 1, Tesshi Yamada
• MGI ID: MGI:3818622
• Gene: Sf1 Location: Chr19:6413952-6428060 bp, + strand Genetic Position: Chr19, 4.48 cM, cytoband B
• Alliance: Sf1^{Gt(pU17)1Teya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141491
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector pU17, which contains a beta-geo cassette flanked by loxP and lox71 sites, was inserted 215 bp upstream of exon 1. A 50% reduction in transcript expression was confirmed by real-time RT-PCR on extracts heterozygous for this allele. (J:141491)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sf1 Mutation: 40 strains or lines available

References

• Original: J:141491 Shitashige M, et al., Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Cancer Sci. 2007 Dec;98(12):1862-7
• All: 1 reference(s)