GlmnGt(OST109778)Lex
Gene trapped Allele Detail
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Symbol: |
GlmnGt(OST109778)Lex |
Name: |
glomulin, FKBP associated protein; gene trap OST109778, Lexicon Genetics |
MGI ID: |
MGI:3817643 |
Gene: |
Glmn Location: Chr5:107696833-107745754 bp, - strand Genetic Position: Chr5, 52.23 cM
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Alliance: |
GlmnGt(OST109778)Lex page
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Mutant Cell Line: |
OST109778 |
Germline Transmission: |
Earliest citation of germline transmission:
J:184206
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Parent Cell Line: |
Lex-1 (ES Cell)
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Strain of Origin: |
129S5/SvEvBrd
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Project Collection: |
Lexicon
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Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
Mutation: |
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Insertion of gene trap vector
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Mutation details: The Lexicon Genetics gene trap vector VICTR48, which contains a splice acceptor sequence followed by the neomycin resistance gene and a double polyadenylation signal, has integrated into the first intron of the glomulin gene upstream of the translation initiation site, which resides in the second exon (Genbank accession NM_133248.1). Western blot analysis confirmed the absence of protein expression in the yolk sac.
(J:184206)
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Inheritance: |
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Recessive |
Sequence Tags: |
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Sequence tag details (1 tag)
Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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Genome Context: |
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Genome Browser view of this mutation
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:184206 Tron AE, et al., The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78 |
All: |
2 reference(s) |
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