Trpm4^tm1.1Knt
Targeted Allele Detail

Summary

• Symbol: Trpm4^tm1.1Knt
• Name: transient receptor potential cation channel, subfamily M, member 4; targeted mutation 1.1, Jean-Pierre Kinet
• MGI ID: MGI:3817408
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^tm1.1Knt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette along with exons 3 through 6. The absence of protein expression was confirmed by western blot analysis on intestine extracts. (J:140991)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 58 strains or lines available

References

• Original: J:140991 Barbet G, et al., The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol. 2008 Oct;9(10):1148-56
• All: 3 reference(s)