Igh^tm1.1Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Michel Cogne
• MGI ID: MGI:3815456
• Synonyms: JH-delta-Emu
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80654
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Igh^tm1Cog homozygotes were mated with EIIa-Cre transgenic mice to remove the floxed neo cassette from the IgH locus. Correct excision of the cassette was confirmed by genomic PCR. (J:80654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:80654 Delpy L, et al., B Cell Development Arrest Upon Insertion of a neo Gene Between J(H) and E micro : Promoter Competition Results in Transcriptional Silencing of Germline J(H) and Complete V(D)J Rearrangements. J Immunol. 2002 Dec 15;169(12):6875-82
• All: 1 reference(s)