Mbd3l2^tm1Gpp
Targeted Allele Detail

Summary

• Symbol: Mbd3l2^tm1Gpp
• Name: methyl-CpG binding domain protein 3-like 2; targeted mutation 1, Gerd P Pfeifer
• MGI ID: MGI:3814990
• Gene: Mbd3l2 Location: Chr9:18341950-18357612 bp, + strand Genetic Position: Chr9, 7.05 cM
• Alliance: Mbd3l2^tm1Gpp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140708
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced 0.95-kb of exon 2, which presents 70% of the gene locus. Southern blotting confirmed correct targeting of the vector. (J:140708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd3l2 Mutation: 15 strains or lines available

References

• Original: J:140708 Jin SG, et al., Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse. Dev Dyn. 2008 Nov;237(11):3435-43
• All: 1 reference(s)