Apobec3^Rfv3-r
Allele Detail

Summary

• Symbol: Apobec3^Rfv3-r
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, resistant
• MGI ID: MGI:3809767
• Gene: Apobec3 Location: Chr15:79775860-79800107 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Apobec3^Rfv3-r page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Not Applicable (Not Applicable)
• Mutation: Not Applicable
• Mutation details: This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2^b mice. Recovery from viremia only is seen in H2^a mice. This allele produces a full length mRNA transcript (including exon 2) that encodes for a protein with potent anti-viral activity. (J:138778)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apobec3 Mutation: 125 strains or lines available

References

• Original: J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
• All: 14 reference(s)