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Apobec3Rfv3-r
Allele Detail
Summary
Symbol: Apobec3Rfv3-r
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, resistant
MGI ID: MGI:3809767
Gene: Apobec3  Location: Chr15:79775860-79800107 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E2
Alliance: Apobec3Rfv3-r page
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Not Applicable (Not Applicable)
Mutation:    Not Applicable
 
Mutation detailsThis gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2b mice. Recovery from viremia only is seen in H2a mice. This allele produces a full length mRNA transcript (including exon 2) that encodes for a protein with potent anti-viral activity. (J:138778)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apobec3 Mutation:  125 strains or lines available
References
Original:  J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory