Selplg^tm2Rpmc
Targeted Allele Detail

Summary

• Symbol: Selplg^tm2Rpmc
• Name: selectin, platelet (p-selectin) ligand; targeted mutation 2, Rodger P McEver
• MGI ID: MGI:3809664
• Synonyms: deltaCD
• Gene: Selplg Location: Chr5:113956597-113970705 bp, - strand Genetic Position: Chr5, 55.59 cM
• Alliance: Selplg^tm2Rpmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138731
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The entire 67 residue cytoplasmic domain was deleted except for the membrane proximal arginine. A codon for a second adjacent arginine followed by two stop codons was inserted. A loxed neo cassette was introduced downstream of exon 2 and sebsequently removed by transient cre expression from properly targeted ES cells. The extracellular domain and the transmembrane domain are expressed normally. (J:138731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Selplg Mutation: 49 strains or lines available

References

• Original: J:138731 Miner JJ, et al., Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood. 2008 Sep 1;112(5):2035-45
• All: 3 reference(s)