Sh2d4a^tm1.1Pdk
Targeted Allele Detail

Summary

• Symbol: Sh2d4a^tm1.1Pdk
• Name: SH2 domain containing 4A; targeted mutation 1.1, Philip D King
• MGI ID: MGI:3809252
• Gene: Sh2d4a Location: Chr8:68729219-68800351 bp, + strand Genetic Position: Chr8, 33.76 cM, cytoband C1
• Alliance: Sh2d4a^tm1.1Pdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139245
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sh2d4a homozygotes were crossed with Tg(CMV-cre)1Ipc transgenic mice that express Cre-recombinase in the germline. The loxP-flanked exon 8 of the gene locus was excised creating a null allele. Gene inactivation was confirmed by immunoblotting of splenic tissue. (J:139245)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d4a Mutation: 21 strains or lines available

References

• Original: J:139245 Lapinski PE, et al., Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol. 2008 Aug 1;181(3):2019-27
• All: 1 reference(s)