Eppk1^tm1Gwi
Targeted Allele Detail

Summary

• Symbol: Eppk1^tm1Gwi
• Name: epiplakin 1; targeted mutation 1, Gerhard Wiche
• MGI ID: MGI:3805682
• Synonyms: epiplakin^-
• Gene: Eppk1 Location: Chr15:75973337-76004395 bp, - strand Genetic Position: Chr15, 35.37 cM
• Alliance: Eppk1^tm1Gwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138604
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 2,697 bp of the second exon of the gene locus was replaced by an in-frame GFP gene, a floxed neomycin resistance cassette and a thymidine kinase gene. Gene inactivation was confirmed by a lack of protein expression in liver and skin. (J:138604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eppk1 Mutation: 39 strains or lines available

References

• Original: J:138604 Spazierer D, et al., Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia. Mol Cell Biol. 2006 Jan;26(2):559-68
• All: 4 reference(s)