Rdh1^tm1Jln
Targeted Allele Detail

Summary

• Symbol: Rdh1^tm1Jln
• Name: retinol dehydrogenase 1 (all trans); targeted mutation 1, Joseph Napoli
• MGI ID: MGI:3804064
• Gene: Rdh1 Location: Chr10:127595595-127604168 bp, + strand Genetic Position: Chr10, 75.21 cM, cytoband D3
• Alliance: Rdh1^tm1Jln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134843
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Transient cre expression in ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:134843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh1 Mutation: 18 strains or lines available

References

• Original: J:134843 Zhang M, et al., Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007 Sep;21(11):2886-96
• All: 1 reference(s)