Nfix^tm1Rmg
Targeted Allele Detail

Summary

• Symbol: Nfix^tm1Rmg
• Name: nuclear factor I/X; targeted mutation 1, Richard M Gronostajski
• MGI ID: MGI:3802570
• Synonyms: Nfix^c
• Gene: Nfix Location: Chr8:85431341-85527086 bp, - strand Genetic Position: Chr8, 41.02 cM, cytoband C1-C2
• Alliance: Nfix^tm1Rmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137651
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. The presence of the neomycin resistance gene reduces Nfix expression by 20-30%. (J:137651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfix Mutation: 54 strains or lines available

References

• Original: J:137651 Campbell CE, et al., The transcription factor Nfix is essential for normal brain development. BMC Dev Biol. 2008;8:52
• All: 17 reference(s)