Mybl2^tm2Sis
Targeted Allele Detail

Summary

• Symbol: Mybl2^tm2Sis
• Name: myeloblastosis oncogene-like 2; targeted mutation 2, Shunsuke Ishii
• MGI ID: MGI:3801680
• Gene: Mybl2 Location: Chr2:162896607-162926608 bp, + strand Genetic Position: Chr2, 84.0 cM
• Alliance: Mybl2^tm2Sis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137631
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells was used to remove the neo cassette leaving exon 5 floxed. (J:137631)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mybl2 Mutation: 114 strains or lines available

References

• Original: J:137631 Yamauchi T, et al., A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 2008 Jul 9;27(13):1852-62
• All: 1 reference(s)