Tg(Myh6-TGFB1*C33S)3Ljf
Transgene Detail

Summary

• Symbol: Tg(Myh6-TGFB1*C33S)3Ljf
• Name: transgene insertion 3, Loren J Field
• MGI ID: MGI:3798069
• Synonyms: MHC-TGFcys³³ser
• Transgene: Tg(Myh6-TGFB1*C33S)3Ljf Location: unknown
• Alliance: Tg(Myh6-TGFB1*C33S)3Ljf page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TGFB1*C33S)3Ljf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFB1 (7040)

  Tgfb1

  (MGI:98725)

  Transgene codes for a protein with a cysteine to serine mutation.

• Mutation details: The mouse alpha-cardiac MHC promoter drives expression of a human TGF-beta1 cDNA encoding a cysteine-to-serine substitution at amino acid residue 33. High levels of transgene-derived mRNA were detected in heart. In addition to line 3, transgenic lines 4, 5 and 6 were also established. (J:61263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:61263 Nakajima H, et al., Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart. Circ Res. 2000 Mar 17;86(5):571-9
• All: 6 reference(s)