Akirin2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Akirin2^tm1Aki
• Name: akirin 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3796161
• Synonyms: Akirin2^flox
• Gene: Akirin2 Location: Chr4:34550937-34566908 bp, + strand Genetic Position: Chr4, 16.8 cM
• Alliance: Akirin2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130487
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette downstream of exon 1. Transient expression of cre in ES cells was used to emove the neo cassette leaving exon 1 floxed. (J:130487)

Expression

In Mice Carrying this Mutation:

35 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akirin2 Mutation: 22 strains or lines available

References

• Original: J:130487 Goto A, et al., Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol. 2008 Jan;9(1):97-104
• All: 7 reference(s)