Akirin1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Akirin1^tm1Aki
• Name: akirin 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3796159
• Synonyms: Akirin1^flox
• Gene: Akirin1 Location: Chr4:123628988-123644092 bp, - strand Genetic Position: Chr4, 57.42 cM, cytoband D1
• Alliance: Akirin1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130487
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 1. Transient cre expression in the ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:130487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akirin1 Mutation: 15 strains or lines available

References

• Original: J:130487 Goto A, et al., Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol. 2008 Jan;9(1):97-104
• All: 1 reference(s)