Bdkrb1^{tm1(BDKRB1)Jfh}
Targeted Allele Detail

Summary

• Symbol: Bdkrb1^{tm1(BDKRB1)Jfh}
• Name: bradykinin receptor, beta 1; targeted mutation 1, J Fred Hess
• MGI ID: MGI:3795262
• Gene: Bdkrb1 Location: Chr12:105570350-105571770 bp, + strand Genetic Position: Chr12, 55.81 cM, cytoband F1
• Alliance: Bdkrb1^{tm1(BDKRB1)Jfh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135789
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Bdkrb1^{tm1(BDKRB1)Jfh} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BDKRB1 (623)

  Bdkrb1

  (MGI:88144)

• Mutation details: The mouse open reading frame was replaced with the human one and a floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. This is a null allele and a knock in allele. (J:135789)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdkrb1 Mutation: 21 strains or lines available

References

• Original: J:135789 Hess JF, et al., Generation and characterization of a humanized bradykinin B1 receptor mouse. Biol Chem. 2006 Feb;387(2):195-201
• All: 1 reference(s)