Tg(GPD1)A1Bir
Transgene Detail

Summary

• Symbol: Tg(GPD1)A1Bir
• Name: transgene insertion A1, Edward H Birkenmeier
• MGI ID: MGI:3795209
• Synonyms: GPDH-A1
• Transgene: Tg(GPD1)A1Bir Location: unknown
• Alliance: Tg(GPD1)A1Bir page

Transgene origin

• Strain of Origin: (C57BL/6J x LT/Sv)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GPD1)A1Bir expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPD1 (2819)

  Gpd1	(MGI:95679)

• Mutation details: The transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line A1 has approximately 6 copies of the transgene. Mice exhibit a much higher level of transgene expression in the cerebral cortex than is normal for the endogenous gene. (J:135002)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:135002 Birkenmeier EH, et al., Tissue- and cell-specific expression of human sn-glycerol-3-phosphate dehydrogenase in transgenic mice. Nucleic Acids Res. 1992 Jun 11;20(11):2819-25
• All: 1 reference(s)