Trp53^tm2Holl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm2Holl
• Name: transformation related protein 53; targeted mutation 2, Monica Hollstein
• MGI ID: MGI:3794646
• Synonyms: Hupki P72, p53^72pro, Trp53^tm1Moho
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm2Holl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135505
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 9 were replaced with corresponding exons from the human gene with a sequence variant in exon 4 that results in a proline at amino acid position 72. A floxed neo cassette used for selection was removed by cre mediated recombination. This mutation corresponds to the prevalent allele among humans of non-Northern European descent. (J:135505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:135505 Reinbold M, et al., Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72. Oncogene. 2008 Apr 24;27(19):2788-94
• All: 7 reference(s)