Tg(APOE-SLCO1B3)1Nki
Transgene Detail

Summary

• Symbol: Tg(APOE-SLCO1B3)1Nki
• Name: transgene insertion 1, The Netherlands Cancer Institute
• MGI ID: MGI:3794297
• Transgene: Tg(APOE-SLCO1B3)1Nki Location: unknown
• Alliance: Tg(APOE-SLCO1B3)1Nki page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Undefined
• Tg(APOE-SLCO1B3)1Nki expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLCO1B3 (28234)

  Slco1b2

  (MGI:1351899)

• Mutation details: Expression of human SLCO1B3 (OATP1B3) cDNA is driven by the human APOE/hepatic control region. Primary expression is in hepatocytes of the liver. (J:184377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184377 van de Steeg E, et al., Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest. 2012 Feb 1;122(2):519-28
• All: 1 reference(s)