Tg(APOE-SLCO1B1)1Nki
Transgene Detail

Summary

• Symbol: Tg(APOE-SLCO1B1)1Nki
• Name: transgene insertion 1, The Netherlands Cancer Institute
• MGI ID: MGI:3794295
• Synonyms: Tg(APOE-SLCOB1)1Ahs
• Transgene: Tg(APOE-SLCO1B1)1Nki Location: unknown
• Alliance: Tg(APOE-SLCO1B1)1Nki page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-SLCO1B1)1Nki expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLCO1B1 (10599)

  Slco1b2

  (MGI:1351899)

• Mutation details: Human SLCO1B (OATP1B1) cDNA expression is driven by the human APOE/hepatic control region. Primary expression is in hepatocytes of the liver. (J:262145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:262145 van de Steeg E, et al., Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab Dispos. 2009 Feb;37(2):277-81
• All: 2 reference(s)