Slc6a6tm1Jaz
Targeted Allele Detail
|
Symbol: |
Slc6a6tm1Jaz |
Name: |
solute carrier family 6 (neurotransmitter transporter, taurine), member 6; targeted mutation 1, Junichi Azuma |
MGI ID: |
MGI:3793961 |
Synonyms: |
taut- |
Gene: |
Slc6a6 Location: Chr6:91661031-91736044 bp, + strand Genetic Position: Chr6, 40.73 cM
|
Alliance: |
Slc6a6tm1Jaz page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:135159
|
Parent Cell Line: |
D3 (ES Cell)
|
Strain of Origin: |
129S2/SvPas
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Exons 2 - 4 were replaced with a neo-cassette via homologous recombination. RT-PCR analysis detected only a truncated transcript including exon 5 but missing exons 2 - 4 in homozygous hearts. Taurine uptake activity was severely diminished in cultured cardiomyocytes from homozygous mice.
(J:135159)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Slc6a6 Mutation: |
319 strains or lines available
|
|
Original: |
J:135159 Ito T, et al., Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol. 2008 May;44(5):927-37 |
All: |
6 reference(s) |
|