Dnmt1^tm1Jamt
Targeted Allele Detail

Summary

• Symbol: Dnmt1^tm1Jamt
• Name: DNA methyltransferase 1; targeted mutation 1, Jaquetta M Trasler
• MGI ID: MGI:3793959
• Synonyms: Dnmt^1s/1o
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^tm1Jamt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76510
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon 1o sequence was replaced with the exon 1s sequence. A neo cassette used for selection was removed by germ line, cre mediated recombination. (J:76510)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 113 strains or lines available

References

• Original: J:76510 Ratnam S, et al., Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development. Dev Biol. 2002 May 15;245(2):304-14
• All: 3 reference(s)