Adgre1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Adgre1^m1Btlr
• Name: adhesion G protein-coupled receptor E1; mutation 1, Bruce Beutler
• MGI ID: MGI:3793322
• Synonyms: F4/80
• Gene: Adgre1 Location: Chr17:57665691-57790527 bp, + strand Genetic Position: Chr17, 29.8 cM
• Alliance: Adgre1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, which was discovered in an ENU mutagenesis screen for defective macrophage function, corresponds to an A-to-G transition at nucleotide position 1776 of the gene, in the 14th of 22 exons, that results in replacement of tyrosine by cysteine at amino acid position 579 of the protein. Macrophages from thioglycolate-elicited peritoneal exudates of homozygous mutant mice exhibit greatly reduced surface expression of the EMR1 (F4/80) protein, and heterozygous macrophages exhibit surface EMR1 expression intermediate between that of wild-type and homozygous cells. (J:135219)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgre1 Mutation: 76 strains or lines available

References

• Original: J:135219 Zhou Z, et al., Reduced macrophage surface expression of F4/80 does not affect resistance to mouse cytomegalovirus (MCMV) or Listeria monocytogenes infection. MGI Direct Data Submission. 2008
• All: 1 reference(s)