Apoc3^tm1(HP)Mae
Targeted Allele Detail

Summary

• Symbol: Apoc3^tm1(HP)Mae
• Name: apolipoprotein C-III; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:3785699
• Synonyms: Apo-Hp2
• Gene: Apoc3 Location: Chr9:46144348-46146934 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Apoc3^tm1(HP)Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134445
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Apoc3^tm1(HP)Mae expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HP (3240)

  Hp	(MGI:96211)

• Mutation details: The human HP gene with a 5' neo cassette and 3' herpes simplex thymadine kinase gene were inserted 30 bp downstream of the poly-adenylation signal. The absence of transcript was confirmed by northern blot analysis. HP expression is detected in many tissues except the bone marrow and spleen roughly recapitulating endogenous expression of the flanking genes at the locus. (J:134445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoc3 Mutation: 18 strains or lines available

References

• Original: J:134445 Hatada S, et al., The influence of chromosomal location on the expression of two transgenes in mice. J Biol Chem. 1999 Jan 8;274(2):948-55
• All: 2 reference(s)