Selenop^tm2Rfb
Targeted Allele Detail

Summary

• Symbol: Selenop^tm2Rfb
• Name: selenoprotein P; targeted mutation 2, Raymond F Burk
• MGI ID: MGI:3785490
• Synonyms: Sepp1^delta240-361
• Gene: Selenop Location: Chr15:3300249-3309992 bp, + strand Genetic Position: Chr15, 1.84 cM
• Alliance: Selenop^tm2Rfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A neo cassette was inserted into exon 5 and a premature stop codon was introduced to truncate the product at codon 239 instead of at codon 361. This truncation eliminates the selenocysteine. The reduction in selenium binding was confirmed by autoradiography with a radioactive selenium tracer. (J:121127)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Selenop Mutation: 22 strains or lines available

References

• Original: J:121127 Hill KE, et al., The selenium-rich C-terminal domain of mouse selenoprotein P is necessary for the supply of selenium to brain and testis but not for the maintenance of whole body selenium. J Biol Chem. 2007 Apr 13;282(15):10972-80
• All: 7 reference(s)