Bmf^tm1Ast
Targeted Allele Detail

Summary

• Symbol: Bmf^tm1Ast
• Name: BCL2 modifying factor; targeted mutation 1, Andreas Strasser
• MGI ID: MGI:3778609
• Synonyms: Bmf^tm1Anvi
• Gene: Bmf Location: Chr2:118359238-118380168 bp, - strand Genetic Position: Chr2, 59.4 cM, cytoband E5
• Alliance: Bmf^tm1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133084
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 4 and an additional loxP site was inserted downstream of exon 2. The neo cassette was removed by germ-line, cre-mediated recombination resulting in a floxed exon 3 and 4. (J:133084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmf Mutation: 21 strains or lines available

References

• Original: J:133084 Labi V, et al., Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med. 2008 Mar 17;205(3):641-55
• All: 1 reference(s)